Publications

Articles

Tharp,  M.E., Malki, S., Bortvin, A. Maximizing the ovarian reserve in mice by evading LINE-1 genotoxicity.  Nature Communications (2020) 11: 330 doi:10.1038/s41467-019-14055-8

Gaysinskaya, V., Miller, B.F., van der Heijden, G.W., Hansen, K.D., Bortvin, A. Transient reduction of DNA methylation at the onset of meiosis in male mice. Epigenetics & Chromatin (2018), 11:15. doi: 10.1186/s13072-018-0186-0

Newkirk, S.J., Lee, S., Grandi, F.C., Gaysinskaya, V., Rosser, J.M., Vanden Berg, N., Hogarth, C.A., Marchetto, M.C.N., Muotri, A.R., Griswold, M.D., Ye, P., Bortvin, A., Gage, F.H., Boeke, J.D., An, W.  Intact piRNA pathway prevents L1 mobilization in male meiosis.  PNAS, (2017); published ahead of print June 19, 2017, doi:10.1073/pnas.1701069114

Malki, S., Tharp, M.E., Bortvin, A.
A Whole-Mount Approach for Accurate Quantitative and Spatial Assessment of Fetal Oocyte Dynamics in Mice.
Biology of Reproduction, (2015), 93(5):113. doi: 10.1095/biolreprod.115.132118

Gaysinskaya, V., Bortvin, A.
Flow Cytometry of Murine Spermatocytes.
Curr. Protoc. Cytom. (2015) 72:7.44.1-7.44.24

Genzor, P., Bortvin, A.
A unique HMG-box domain of mouse Maelstrom binds structured RNA but not double stranded DNA.
PLOS ONE. (2015) 10(3):e0120268

Castaneda, J., Genzor, P., van der Heijden, G.W., Sarkeshik, A., Yates, J.R., Ingolia, N.T., Bortvin, A.
Reduced pachytene piRNAs and translation underlie spermiogenic arrest in Maelstrom mutant mice.
The EMBO Journal. (2014) 33(18):1999-2019

Malki, S., van der Heijden, G.W., O’Donnell, K.A., Martin, S.L., Bortvin, A.
A Role for Retrotransposon LINE-1 in Fetal Oocyte Attrition in Mice.
Developmental Cell. (2014) 29(5):521-33

Gaysinskaya, V, Soh, I.Y., van der Heijden, G.W., Bortvin, A.
Optimized flow cytometry isolation of murine spermatocytes.
Cytometry A. (2014) 85(6):556-65

Guan, L., van der Heijden, G.W., Bortvin, A., Greenberg, M.M.
Intracellular detection of Cytosine incorporation in genomic DNA by using 5-ethynyl-2′-deoxycytidine.
Chembiochem. (2011) 12(14):2184-90.

Vranis, N.M., van der Heijden, G.W., Malki, S., Bortvin, A.
Synaptonemal Complex Length Variation in Wild-Type Male Mice.
Genes. (2010) 1(3):505-520

Aravin, A.A., van der Heijden, G.W., Castaneda, J., Vagin, V.V., Hannon, G.J., Bortvin, A.
Cytoplasmic Compartmentalization of the Fetal piRNA Pathway in Mice.
PLoS Genet. (2009) 5(12):e1000764

Soper, S.F.C., van der Heijden, G.W., Hardiman, T.C., Goodheart, M., Martin, S.L., de Boer, P., Bortvin, A.
Mouse Maelstrom, a Component of Nuage, Is Essential for Spermatogenesis and Transposon Repression in Meiosis.
Developmental Cell. (2008) 15(2):285-297

Reviews

Tharp, M.E., Bortvin, A. De novo DNA Methylation: Who’s Your DADdy? Trends in Genetics (2019) https://doi.org/10.1016/j.tig.2019.09.001

Woltjen, K., Bortvin, A. Editorial overview: Embroidering the canvas of life. Curr Opin Genet Dev. (2018) 52:ii-iv

Tharp, M., Bortvin, A.
DjPiwiB: A Rich Nuclear Inheritance for Descendants of Planarian Stem Cells.
Developmental Cell (2016) 37(3):204-206.

Bortvin, A.
PIWI-interacting RNAs (piRNAs) - a mouse testis perspective.
Biochemistry (Mosc.) (2013) 78(6):592-602

Castaneda, J., Genzor, P., Bortvin, A.
piRNAs, transposon silencing, and germline genome integrity.
Mutat Res. (2011) 714(1-2):95-104.

van der Heijden, G.W., Castaneda, J., Bortvin, A.
Bodies of evidence - compartmentalization of the piRNA pathway in mouse fetal prospermatogonia.
Curr Opin Cell Biol. (2010) 22(6):752-7.

van der Heijden G. W., Bortvin, A.
Defending the Genome in Tudor Style.
Developmental Cell (2009) 17(6):745-6

van der Heijden, G.W., Bortvin, A.
Transient relaxation of transposon silencing at the onset of mammalian meiosis.
Epigenetics (2009) 4(2):76-9.

Book Chapters

Malki, S., Bortvin, A.
Epigenetics and Transposon Control in the Mammalian Germline.
In Epigenetics in Human Reproduction and Development. p.1-33, World Scientific 2017.